Detalhe da pesquisa
1.
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Bioorg Med Chem Lett
; 29(4): 560-562, 2019 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30616904
2.
Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1.
Bioorg Med Chem Lett
; 27(14): 3190-3195, 2017 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545974
3.
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1.
Bioorg Med Chem Lett
; 27(20): 4755-4759, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28927796
4.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem J
; 473(13): 1869-79, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27099339
5.
Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells.
J Cell Sci
; 127(Pt 6): 1346-56, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24424027
6.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27086121
7.
Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukemia: clinical significance and progress to date.
Med Res Rev
; 35(3): 586-618, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25418875
8.
Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.
ACS Med Chem Lett
; 11(4): 497-505, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292556
9.
Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.
Bioorg Med Chem Lett
; 19(10): 2664-7, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362836
10.
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
Bioorg Med Chem Lett
; 19(20): 5945-9, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19733067
11.
Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.
Bioorg Med Chem
; 17(18): 6590-605, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19695884
12.
DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.
Cancer Cell
; 35(3): 519-533.e8, 2019 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30889383
13.
Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.
Cancer Res
; 79(17): 4491-4502, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273064
14.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
15.
Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
Bioorg Med Chem Lett
; 18(9): 2924-9, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18411049
16.
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
Bioorg Med Chem Lett
; 18(9): 2920-3, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18407496
17.
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.
Bioorg Med Chem Lett
; 18(9): 2916-9, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18406614
18.
Artificial Intelligence in Drug Design-The Storm Before the Calm?
ACS Med Chem Lett
; 9(12): 1150-1152, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613315
19.
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Cell Rep
; 22(13): 3641-3659, 2018 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590629
20.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30403352